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FungiFlex®
Mold Panel

Plasma cfDNA detection of 14 species of invasive mold pathogens, including Aspergillus, Mucorales, Fusarium, and Scedosporium/Lomentospora.

K2-EDTA
Plasma
Turnaround
<24h
after sample receipt
Test Code
FM001
CPT Code
87798

Results Reported

14 species of molds reported in 7 clinically actionable groups

Organism reported Targets included
Aspergillus flavusA. flavus
Aspergillus fumigatusA. fumigatus
Aspergillus nigerA. niger
Aspergillus terreusA. terreus
Fusarium spp.F. verticillioides, F. oxysporum, F. solani
ScedosporiumScedosporium spp., Lomentospora prolificans
Mucorales agentsMucor circinelloides, Rhizomucor miehei, Rhizopus microsporus, Rhizopus oryzae, Cunninghamella bertholletiae

Clinical Utility

A plasma-based mold cfDNA assay offers a rapid, noninvasive way to support the diagnosis of invasive fungal infection.

Invasive fungal infections can present as a range of syndromes, including invasive rhinosinusitis, pneumonia, central nervous system disease, and skin or soft tissue involvement. As the number of patients undergoing transplantation and receiving immunosuppressive therapy continues to grow, so does the at-risk population and the incidence of IFIs. Aspergillus species and Mucorales are among the most frequent causes, and are usually diagnosed by sampling deep tissues such as lung — often through biopsy, or by bronchoalveolar lavage (BAL) as a less invasive surrogate. Both approaches carry procedural risk and may be nondiagnostic when paired with conventional assays.

Specimen Instructions

Sample requirements

Container type
K2-EDTA (Lavender Top)
Sample volume
>2 mL Plasma or >4 mL Whole Blood
Preferred specimen
  • Whole Blood If received by the Zepto laboratory < 24 hours after collection
  • Plasma If received by the Zepto laboratory > 24 hours after collection
Sample Sendout Instructions (PDF)

Sample stability

Sample type Temperature Stability
Whole Blood Ambient Up to 24 hours
Plasma Ambient Up to 96 hours
Frozen Plasma ≤ −20°C Up to 4 weeks

Storage & shipping

  • If shipment will be delayed beyond 96 hours, freeze plasma at ≤ −20°C and ship on dry ice.

  • All specimens must be accompanied by a Zepto Test Requisition form and labeled with the patient's name, another unique identifier, and collection time.

  • Specimens must be triple packaged according to IATA Instruction 650. Ship the specimen using UPS Next Day Air Early or FedEx First Overnight.

  • Frozen specimens must be shipped on dry ice inside an appropriate insulated shipping container.

How to order this test

Forms & More Information

Test Requisition Form (PDF) Sample Sendout Instructions (PDF) Medical Test Menu (PDF)
NOT FDA-CLEARED · THIS TEST WAS DEVELOPED AND ITS PERFORMANCE CHARACTERISTICS ESTABLISHED BY ZEPTO LIFE TECHNOLOGY, IN A MANNER CONSISTENT WITH CLIA REQUIREMENTS.

References

01Young, J.A.H. et al. Extrapulmonary and Other Pneumocystis jirovecii Infections Diagnosed via Fungal Cell-Free DNA Using Giant Magnetoresistance Detection. Journal of Fungi, 2026. doi.org/10.3390/jof12060435
02Vergidis, P. et al. A Novel Giant Magnetoresistance—Enabled Multiplex Polymerase Chain Reaction Assay for the Diagnosis of Invasive Fungal Infection Open Forum Infectious Diseases, 2025. academic.oup.com/ofid
03Vergidis, P. et al. Diagnosis of Invasive Fungal Infection Using a Cell-Free DNA Assay Coupled with GMR Lab-on-a-Chip Technology. Presented at ECCMID, 2024.
04Vergidis, P. et al. Detection of Aspergillus fumigatus Cell-Free DNA Using Giant Magnetoresistance Technology. Presented at Advances Against Aspergillosis, 2024.